In conversation with Mark Cuban

By the end of calendar year 2025, total U.S. federal debt will be approximately $40 trillion, and at an average interest rate of about 4% this will imply on the order of $1.6 trillion per year in federal interest expense.

“which means that by the end of 2025, we could be staring at $40 trillion of federal debt. And if you do the math on that, at 4% interest, it's 1.6 trillion a year of interest expense a year just on interest expense on the outstanding debt”

Over the near term (the next few years from 2024), U.S. interest rates will fall below 4%, driven by getting inflation under control, which will materially reduce federal interest costs relative to keeping rates above 4%.

“there's only a couple of ways to reduce the deficit. One, you get inflation under control and that reduces interest rates. And that's going to work in our favor. And I think that's happening now if it's Trillion dollars that, you know, if interest rates go below 4%, that saves a lot of money”

If Kamala Harris becomes president, her administration will actively deploy technologies such as AI (and to a lesser extent blockchain) across government with the stated goals of increasing military capability and economic growth, and this will be framed as an alternative to pure spending increases as the primary way to grow the economy.

“I think, um, you're going to see a lot of reduction. I'm trying to think of the best way to say it. She knows that technology is the ultimate driver of success and if she supports new technologies... And you heard that again in Pittsburgh, she wants she mentioned blockchain, but more importantly, she mentioned AI and how AI is key to us being a dominant military... and to have our economy grow... and that there truly are ways to grow the economy without just more spending.”

If Kamala Harris wins the presidency, her administration will pursue a program of implementing modern technology (especially AI) inside federal agencies to improve efficiency, rather than pursuing large-scale headcount cuts or department eliminations, and this tech-driven efficiency program will be a noticeable feature of her administration relative to a hypothetical Trump administration.

“We have yet to have a president that fully understands technology. I'm not here to tell you that Kamala Harris is a geek. She's not. But she understands the impact. And she has a lot of people who truly are geeks around her, around her. And she truly believes that implementing technology is a way to improve efficiency... I think you will get that from the Harris administration, as opposed to Donald just talking about the AI and how much energy it consumes.”

If a large-scale, Venetian-style casino complex is successfully built in Dallas with the American Airlines Center integrated into it, the Dallas Mavericks franchise plus associated arena asset will be valued at roughly $20 billion, of which Mark Cuban will own about 27%.

“If we're able to build a Venetian type casino in Dallas with an American Airlines center in the middle of it. The valuation is $20 billion, but I own 27% of that.”

Mark Cuban Cost Plus Drug Company will experience extremely rapid, accelerating growth in revenue and/or prescription volume ("double or triple hockey-stick" growth) and will continue to take significant business away from traditional pharmacy benefit managers over the coming years.

“our path is hockey stick double triple hockey stick. And so we're taking business from them.”

If government policy requires full pricing transparency in all healthcare and pharmacy-related contracts, average healthcare and drug prices will decline by roughly 30–40%, leading to materially lower out-of-pocket costs for consumers and lower total government healthcare spending.

“by working, by requiring transparency in all contracts signed by anybody, anywhere in terms of pricing, you are going to see the same impact on across the board pricing of a decrease of 3,040%. And so all of that is going to reduce out-of-pocket spending for everybody, reduce government spending for everybody, and have a net positive impact.”

As AI systems advance, standalone "agent" startups will not remain durable independent products; instead, agent capabilities will become features embedded in broader AI platforms, and advanced AI systems will automatically generate and manage agents for users.

“I think you can put all these vertical agents together to do all these different things. But agents are just going to be a feature, not a product. Because inherently in AI, as it advances and gets smarter, then it's going to be able to create its own agents for its users and go forward from there.”

Over the next decade or so, the number of AI models will grow to tens of millions, with individuals (including children) commonly having their own personalized models embedded in devices such as toys (e.g., a teddy bear), while the eventual dominant hosting platforms for these models remain uncertain.

“I think there are going to be tens of millions of models. Everybody's going to have a model. Your kids are going to have models. You know, their little, um, invisible friend is going to be a model that's in a, you know, a teddy bear, um, that they grow up with. So there's going to be an unlimited number of models, but we don't know who the winners are going to be to host those models.”